Evaluation of a quick and easy model to determine the intrinsic ability of clinical strains to generate active TB has been set by assuming that this is linked to the fitness of Mycobacterium tuberculosis strain at the innate phase of the infection. Thus, the higher the bacillary load, the greater the possibility of inducting liquefaction, and thus active TB, once the adaptive response is set. Up to 7 clinical M.tuberculosis strains isolated in Spain within the last 10 years were evaluated using this model. The results showed that the fitness obtained after low dose aerosol administration in the presence of the innate immune response is the most predictive factor for determining the virulence of clinical strains, and we do consider this gives support to a mechanism of the induction of active TB derived from the dynamic hypothesis of latent tuberculosis infection.
This work have been possible with the involvement of several groups within the CIBERES Spanish Consortium, the MOSIMBIO group and the European Community’s 7th Framework Programme (STOPLATENT-TB project, Grant Agreement 200999).
Do you want to read it? Please downloaded it HERE!
AGENDA: Do not miss!!
We will celebrate the World TB Day
at Palau Macaya, Barcelona (thanks to the LaCaixa Foundation), on 22th March 2017, from 10 am to 3 pm.
Organized by the FUITB.